A new tetracycline antibiotic with antitumor activity. I. Taxonomy and fermentation of the producing strain, isolation and characterization of SF2575.

نویسندگان

  • M Hatsu
  • T Sasaki
  • H Watabe
  • S Miyadoh
  • M Nagasawa
  • T Shomura
  • M Sezaki
  • S Inouye
  • S Kondo
چکیده

A new antitumor antibiotic SF2575 has been isolated from a culture filtrate of Streptomyces sp. SF2575. The molecular formula was determined to be C40H43NO15 by elemental analysis, mass and 13C NMR spectral analyses. The spectral data revealed SF2575 to be a new tetracycline antibiotic. It was active against Gram-positive bacteria and exhibited antitumor activity against P388 leukemia in mice.

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عنوان ژورنال:
  • The Journal of antibiotics

دوره 45 3  شماره 

صفحات  -

تاریخ انتشار 1992